Гидрогели на основе хитозана и их применение в медицине
Ключевые слова:
гидрогели, хитозан, доставка лекарств, раневые покрытия
Аннотация
Хитозан – природный биополимер, полисахарид, продукт деацетилирования хитина. Хитозан является нетоксичным, биосовместимым и биодеградируемым полимером, обладающим высокой биологической активностью и устойчивостью в природной среде. Кроме того, хитозан является недорогим веществом, который получают из природных возобновляемых ресурсов. Благодаря всем этим свойствам, хитозан широко применяется в практической медицине, например, в виде гидрогелевых лекарственных форм в сочетании с природными и синтетическими полимерами.
Данный обзор посвящен полимерным гидрогелевым материалам на основе хитозана. Особое внимание уделено получению и применению раневых покрытий на его основе для лечения и быстрого заживления дефектов кожного покрова. Применение гидрогелевых раневых покрытий на основе полисахарида позволяет создавать защитную оболочку на поверхности различных ран, пролонгированно доставлять к ним антибактериальные агенты, пептиды и другие активные вещества, что существенно повышает эффективность их лечения. Описаны бактерицидные и сорбционные свойства гидрогелей на основе хитозана, установленные в экспериментальных и клинических исследованиях.
Литература
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29 Legonkova OA, Alekseev AA (2015) Bulletin of Roszdravnadzor [Vestnik Roszdravnadzora] 6:66-68. (In Russian)
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37 Kean T, Thanou M (2010) Adv Drug Delivery Rev 62(1):3-11. Crossref
38 Deepachitra R, Pujitha Lakshmi R, Sivaranjani K, Helan Chandra J, Sastry TP (2015) J Chem Pharm Sci 8(2):324-329.
39 Dai T, Tanaka M, Huang YY, Hamblin MR (2011) Expert Rev Anti Infect Ther 9(7):857-879. Crossref
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41 Hamdine M, Heuzey MC, Bégin A (2006) Rheol Acta 45(5):659-675. Crossref
42 Paul W, Sharma CP (2004) Trends in Biometerials and Artificial Organs 18(1):18-23.
43 Raafat D, Von Bargen K, Haas A, Sahl HG (2008) Appl Environ Microbiol 74:3764-3773. Crossref
44 Goy RC, De Britto D, Assis OBG (2009) Polimeros 19(3):241-247. Crossref
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46 Croisier F, Jérôme C (2013) Eur Polym J 49(4):780–792. Crossref
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52 Anisha BS, Biswas R, Chennazhi KP, Jayakumar R (2013) Int J Biol Macromol 62:310-320. Crossref
53 Sámano-Valencia C, Martinez-Castanon GA, Martínez-Martínez RE, Loyola-Rodríguez JP, Reyes-Macías JF, et al (2013) Mater Lett 106:413-416. Crossref
54 Sudheesh Kumar PT, Lakshmanan VK, Anilkumar TV, Ramya C, Reshmi P, et al (2012) ACS Appl Mater Inter 4(5):2618-2629. Crossref
55 Aziz MA, Cabral JD, Brooks HJL, Moratti SC, Hanton LR (2012) Antimicrob Agents Chemother 56(1):280-287. Crossref
56 Mochalova AE, Budruev AV, Oleinik AV, Smirnova LA (2009) Promising materials [Perspektivnyye materialy] 5:61-65. (In Russian)
57 Miguel SP, Ribeiro MP, Brancal H, Coutinho P, Correia IJ (2014) Carbohydr Polym 111:366-373. Crossref
58 Ahmed S, Ikram S (2016) Achiev Life Sci 10(1):27-37. Crossref
59 Arteche Pujana M, Pérez-Álvarez L, Cesteros Iturbe LC, Katime I (2013) Carbohydr Polym 94:836-842. Crossref
60 Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R (2004) Eur J Pharm Biopharm 57(1):19-34. Crossref
61 Abbasipour M, Mirjalili M, Khajavi R, Majidi MM (2014) J Eng Fibers Fabr 9(1):124-130. Crossref
62 Wang L, Khor E, Wee A, Lim LY (2002) J Biomed Mater Res 63(5):610-618. Crossref
63 Mi FL, Shyu SS, Wu YB, Lee ST, Shyong JY, Huang RN (2001) Biomaterials 22(2):165–173. Crossref
64 Hao JY, Mi FL, Shyu SS, Wu YB, Schoung JY (2002) J Biomed Mater Res 59(3):438-449. Crossref
65 Ishihara M, Ono K, Sato M, Nakanishi K, Saito Y, et al (2001) Wound Repair and Regeneration 9(6):513-521. Crossref
66 Obara K, Ishihara M, Ishizuka T, Fujita M, Ozeki Y, Maehara T, Saito Y, Yura H, Matsui T, Hattori H, Kikuchi M, Kurita A (2003) Biomaterials 24(20):3437-3444. Crossref
67 Kamoun EA, Chen X, Mohy Eldin MS, Kenawy ERS (2015) Arabian J Chem 8(1):1-14. Crossref
68 El Salmawi KM (2007) J Macromol Sci Part A Pure Appl Chem 44:541-545. Crossref
69 Khorasani MT, Joorabloo A, Moghaddam A, Shamsi H, Mansoori Moghadam Z (2018) Int J Biol Macromol 114:1203-1215. Crossref
70 Chen SH, Tsao CT, Chang CH, Lai YT, Wu MF, et al (2013) Mater Sci Eng C 33:2584-2594. Crossref
71 Radhakumary C, Antonty M, Sreenivasan K (2011) Carbohydr Polym 83:705-713. Crossref
72 Mayorova AV, Sysuev BB, Khanalieva IA, Vikhrova IV (2018) Pharmacy & Pharmacology [Farmatsiya i farmakologiya] 1:4-32. (In Russian). Crossref
73 Prokopchuk NR, Melamed VD, Prishchepenko DV (2017) Proceedings of BSTU [Trudy BGTU]1:15-22. (In Russian)
74 Zhao R, Li X, Sun B, Zhang Y, Zhang D, et al (2014) Int J Biol Macromol 68:92-97. Crossref
2 Bhowmik D, Gopinath H, Kumar BP, Duraivel S, Kumar KPS (2012) Pharma Innovation 1(10):24-32.
3 Chanda J (1994) Biomaterials 15:465-465. Crossref
4 Oh JK, Lee DI, Park JM (2009) Prog Polym Sci 34:1261-1282. Crossref
5 Kumari A, Yadav SK, Yadav SC (2010) Colloids Surf B 75:1-18. Crossref
6 Peppas NA, Bures P, Leobandung W, Ichikawa H (2000) Eur J Pharm Biopharm 50:27-46. Crossref
7 Hoffman AS (2012) Adv Drug Delivery Rev 64:18-23. Crossref
8 Gao L, Gan H, Meng Z, Gu R, Wu Z, et al (2014) Colloids Surf B 117:398-405. Crossref
9 Wichterle O, Lím D (1960) Nature 185:117-118. Crossref
10 Lim F, Sun AM (1980) Science 210:908-910. Crossref
11 Caló E, Barros JMSD, Fernández-Gutiérrez M, San Román J, Ballamy L, Khutoryanskiy VV (2016) RSC Adv 6(60):55211-55219. Crossref
12 Boateng JS, Matthews KH, Stevens HNE (2008) J Pharm Sci 97:2892-2923. Crossref
13 Winter GD (1962) Nature 193:293-294. Crossref
14 Kamoun EA, Kenawy ERS, Chen X (2017) J Adv Res 8:217-233. Crossref
15 Huang S, Fu X (2010) J Control Release 142:149-159. Crossref
16 Seaman S (2002) J Am Podiatr Med Assoc 92(1):24-33. Crossref
17 Azad AK, Sermsintham N, Chandrkrachang S, Stevens WF (2004) J Biomed Mater Res B 69(2):216-222. Crossref
18 Grigoryeva MV (2011) Biotechnology [Biotekhnolohiya] 2:9-23. (In Russian)
19 Pawar HV, Tetteh J, Boateng JS (2013) Colloids Surf B 102:102-110. Crossref
20 Caccavo D, Cascone S, Lamberti G, Barba AA (2015) Mol Pharm 12(2):473-483. Crossref
21 Koehler J, Brandl FP, Goepferich AM (2018) Eur Polym J 100:1-11. Crossref
22 Jin SG, Yousaf AM, Kim KS, Kim DW, Kim DS, et al (2016) Int J Pharm 501(1-2):160-166. Crossref
23 Nolff MC, Albert R, Reese S, Meyer-Lindenberg A (2018) Vet Comp Orthop Traumatol 31(4):22-238. Crossref
24 Caló E, Khutoryanskiy VV (2015) Eur Polym J 65:252-267. Crossref
25 Vinnik YuS, Markelova NM, Tyuryumin VS (2013) Siberian Medical Review [Sibirskoye meditsinskoye obozreniye] 1:18-24. (In Russian)
26 Osikov MV, Simonyan EV, Grigoryeva GP, Saedgalina OT, Nozhkina NN (2014) Fundamental Research [Fundamental’nyye issledovaniya] 10:1632-1639.
27 Kumar A, Wang X, Nune KC, Misra RDK (2017) Int Wound J 14(6):1076-1087. Crossref
28 Vinnik YuS, Markelova NM, Solovyova NS, Shishatskaya EI, Kuznetsov MN, Zuev AP (2015) Surgery News [Novosti khirurgii] 5:552-558. (In Russian). Crossref
29 Legonkova OA, Alekseev AA (2015) Bulletin of Roszdravnadzor [Vestnik Roszdravnadzora] 6:66-68. (In Russian)
30 Blenov AV (2006) Surgery News [Novosti khirurgii] 14(1):9-19. (In Russian)
31 Anjum S, Arora A, Alam MS, Gupta B (2016) Int J Pharm 508(1-2):92-101. Crossref
32 Pinho E, Soares G (2018) J Mater Chem B 6(13):1887-1898. Crossref
33 Ou K, Wu X, Wang B, Meng C, Dong X, He J (2017) Cellulose 24(11):5211-5224. Crossref
34 Thakur VK, Thakur MK (2014) ACS Sustain Chem Eng 2(12):2637-2652. Crossref
35 Shablin DV, Pavlenko SG, Evglevsky AA, Bondarenko PP, Khuranov AA (2013) Fundamental Research [Fundamental’nyye issledovaniya] 12:361-365. (In Russian)
36 Kumar MNVR, Muzzarelli RAA, Muzzarelli C, Sashiwa H, Domb AJ (2004) Chem Rev 104(12):6017-6084. Crossref
37 Kean T, Thanou M (2010) Adv Drug Delivery Rev 62(1):3-11. Crossref
38 Deepachitra R, Pujitha Lakshmi R, Sivaranjani K, Helan Chandra J, Sastry TP (2015) J Chem Pharm Sci 8(2):324-329.
39 Dai T, Tanaka M, Huang YY, Hamblin MR (2011) Expert Rev Anti Infect Ther 9(7):857-879. Crossref
40 Durán-Lobato M, Martín-Banderas L, Gonçalves LMD, Fernández-Arévalo M, Almeida AJ (2015) J Nanopart Res 17(2):2875-2889. Crossref
41 Hamdine M, Heuzey MC, Bégin A (2006) Rheol Acta 45(5):659-675. Crossref
42 Paul W, Sharma CP (2004) Trends in Biometerials and Artificial Organs 18(1):18-23.
43 Raafat D, Von Bargen K, Haas A, Sahl HG (2008) Appl Environ Microbiol 74:3764-3773. Crossref
44 Goy RC, De Britto D, Assis OBG (2009) Polimeros 19(3):241-247. Crossref
45 Chung YC, Chen CY (2008) Bioresour Technol 99:2806-2814. Crossref
46 Croisier F, Jérôme C (2013) Eur Polym J 49(4):780–792. Crossref
47 Ahmed S (2014) Journal of Applicable Chemistry 3(2):493-503.
48 Mozalewska W, Czechowska-Biskup R, Olejnik AK, Wach RA, Ulański P (2017) Radiat Phys Chem 134:1-7. Crossref
49 Simões D, Miguel SP, Ribeiro MP, Coutinho P (2018) Eur J Pharm Biopharm 127:130-141. Crossref
50 Bukina YuA, Sergeeva EA (2012) Bulletin of the KTU [Vestnik KTU] 7:125-128. (In Russian)
51 Tyliszczak B, Drabczyk A, Kudłacik-Kramarczyk S, Bialik-Wąs K, Kijkowska R, Sobczak-Kupiec A (2017) Colloids Surf B 160:325-330. Crossref
52 Anisha BS, Biswas R, Chennazhi KP, Jayakumar R (2013) Int J Biol Macromol 62:310-320. Crossref
53 Sámano-Valencia C, Martinez-Castanon GA, Martínez-Martínez RE, Loyola-Rodríguez JP, Reyes-Macías JF, et al (2013) Mater Lett 106:413-416. Crossref
54 Sudheesh Kumar PT, Lakshmanan VK, Anilkumar TV, Ramya C, Reshmi P, et al (2012) ACS Appl Mater Inter 4(5):2618-2629. Crossref
55 Aziz MA, Cabral JD, Brooks HJL, Moratti SC, Hanton LR (2012) Antimicrob Agents Chemother 56(1):280-287. Crossref
56 Mochalova AE, Budruev AV, Oleinik AV, Smirnova LA (2009) Promising materials [Perspektivnyye materialy] 5:61-65. (In Russian)
57 Miguel SP, Ribeiro MP, Brancal H, Coutinho P, Correia IJ (2014) Carbohydr Polym 111:366-373. Crossref
58 Ahmed S, Ikram S (2016) Achiev Life Sci 10(1):27-37. Crossref
59 Arteche Pujana M, Pérez-Álvarez L, Cesteros Iturbe LC, Katime I (2013) Carbohydr Polym 94:836-842. Crossref
60 Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R (2004) Eur J Pharm Biopharm 57(1):19-34. Crossref
61 Abbasipour M, Mirjalili M, Khajavi R, Majidi MM (2014) J Eng Fibers Fabr 9(1):124-130. Crossref
62 Wang L, Khor E, Wee A, Lim LY (2002) J Biomed Mater Res 63(5):610-618. Crossref
63 Mi FL, Shyu SS, Wu YB, Lee ST, Shyong JY, Huang RN (2001) Biomaterials 22(2):165–173. Crossref
64 Hao JY, Mi FL, Shyu SS, Wu YB, Schoung JY (2002) J Biomed Mater Res 59(3):438-449. Crossref
65 Ishihara M, Ono K, Sato M, Nakanishi K, Saito Y, et al (2001) Wound Repair and Regeneration 9(6):513-521. Crossref
66 Obara K, Ishihara M, Ishizuka T, Fujita M, Ozeki Y, Maehara T, Saito Y, Yura H, Matsui T, Hattori H, Kikuchi M, Kurita A (2003) Biomaterials 24(20):3437-3444. Crossref
67 Kamoun EA, Chen X, Mohy Eldin MS, Kenawy ERS (2015) Arabian J Chem 8(1):1-14. Crossref
68 El Salmawi KM (2007) J Macromol Sci Part A Pure Appl Chem 44:541-545. Crossref
69 Khorasani MT, Joorabloo A, Moghaddam A, Shamsi H, Mansoori Moghadam Z (2018) Int J Biol Macromol 114:1203-1215. Crossref
70 Chen SH, Tsao CT, Chang CH, Lai YT, Wu MF, et al (2013) Mater Sci Eng C 33:2584-2594. Crossref
71 Radhakumary C, Antonty M, Sreenivasan K (2011) Carbohydr Polym 83:705-713. Crossref
72 Mayorova AV, Sysuev BB, Khanalieva IA, Vikhrova IV (2018) Pharmacy & Pharmacology [Farmatsiya i farmakologiya] 1:4-32. (In Russian). Crossref
73 Prokopchuk NR, Melamed VD, Prishchepenko DV (2017) Proceedings of BSTU [Trudy BGTU]1:15-22. (In Russian)
74 Zhao R, Li X, Sun B, Zhang Y, Zhang D, et al (2014) Int J Biol Macromol 68:92-97. Crossref
Опубликован
2020-05-04
Как цитировать
АbilovaG., Makhayeva, D., Irmukhametova, G., & Khutoryanskiy, V. (2020). Гидрогели на основе хитозана и их применение в медицине. Вестник КазНУ. Серия химическая, 97(2), 16-28. https://doi.org/https://doi.org/10.15328/cb1100
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