Composite detergents with antibacterial properties based on mixtures of cetylpyridinium chloride with Genapol

Keywords: surface activity, surfactants, detergents, Genapol, cetylpyridinium chloride, antibacterial activity, zone of inhibition, pathogenic microorganisms

Abstract

This study focuses on the properties of the nonionic surfactant Genapol and the cationic surfactant cetylpyridinium chloride (CPC) to develop a composite detergent with bactericidal activity. Research includes studying the properties of CPC and Genapol solutions, creating composite mixtures with different concentration ratios and assessing the bactericidal effectiveness of the resulting detergents.

The main foaming agents CPC and Genapol were used without purification, which emphasizes their high biodegradability. Various tests, including surface tension measurements, contact angle evaluation and pH measurements, were carried out at room temperature to evaluate the properties of surfactants and surfactant mixtures.

The results show that CPC exhibits foaming, emulsifying and bactericidal properties due to its high surface activity and adsorption capacity. Genapol has the advantages of high surface activity at different pH levels, excellent foaming and emulsifying properties. The combination of these surfactants in a complex detergent creates a universal cleaner with antibacterial properties independent of pH and environmental harshness. The bactericidal effect of solutions of CPC Genapol mixtures was also determined.

The results show that the composite solution exhibits a noticeable bactericidal effect with zones of growth inhibition ranging from 13.5±0.5 mm to 17±0.1 mm. The greatest antibacterial activity was observed against Micobacterium citreum and Bacillus subtilis. Sarcina flava and Staphylococcus aureus showed similar growth inhibition results.

References

1 Soldatenkov AT, Le TA, Truong HH, Komarova AI, Mandal TK, Kolyadina NM (2014) Detergents, cleaning and disinfectants. Applied organic chemistry [Moyushchiye, chistyashchiye i dezinfitsiruyushchiye veshchestva. Prikladnaya organicheskaya khimiya.]. Vietnam National University Publishing House, Hanoi, Vietnam. (In Russian)

2 Lange KR (2016) Surfactants. Synthesis, properties, analysis, application [Poverkhnostno-aktivnyye veshchestva. Sintez, svoystva, analiz, primeneniye]. Professiya, St. Petersburg, Russia. (In Russian)

3 Kogawa AC, Cernic BG, do Couto LGD, Salgado HRN (2017) Saudi Pharmaceutical Journal 25(6)934–938. Crossref

4 Nikolaev PV (2007) Fundamentals of chemistry and technology for the production of synthetic detergents [Osnovy khimii i tekhnologii proizvodstva sinteticheskikh moyushchikh sredstv]. Ivanovo State University of Chemical Technology, Ivanovo, Russia. (In Russian)

5 Saraji M, Shirvani N (2017) Int J Cosmetic Sci 39(1)36–41. Crossref

6 Shestopalov NV, Panteleeva LG, Sokolova NF, Abramova IM, Lukichev SP (2015) Federal clinical recommendations for the selection of chemical disinfectants and sterilization for use in medical organizations [Federal'nyye klinicheskiye rekomendatsii po vyboru khimicheskikh sredstv dezinfektsii i sterilizatsii dlya ispol'zovaniya v meditsinskikh organizatsiyakh]. Moscow, Russia. (In Russian)

7 Pradhan AR, Bhattacharyya A (2017) J Clean Prod 150:127 134. Crossref

8 Ospanova ZhB, Adilbekova AO, Musabekov KB, Tulegenova GU (2014) Chem Bull Kaz Nat Univ 1(73):33-39. (In Russian). Crossref

9 Kumargalieva SSh, Ospanova ZhB, Abramova O, Musabekov KB (2006) Chem Bull Kaz Nat Univ 2(42). (In Russian)

10 Holmberg K, Jensson B, Kronberg B, Lindman B (2015) Surfactants and polymers in aqueous solutions (translation from English edited by Summ BD). Binom, Moscow, Russia. 310 pp.

11 Falk NA (2019) J Surfactants Deterg 22(5)1119–1127. Crossref

12 Corazza M, Lauriola MM, Zappaterra M, Bianchi A, Virgili A (2010) Journal of the European Academy of Dermatology and Venereology: JEADV 24(1):1–6. Crossref

13 Khan S, Amin F, Amin R, Kumar N (2024) Polymers-Basel 16(5):588. Crossref

14 Rambo MKD, Lins RF, N Silva FL, Alonso A, Rambo MCD, C Leal JE, de Sousa-Neto D (2024) Braz J Biol 84:e278013. Crossref

15 Di Lodovico S, Dotta TC, Cellini L, Iezzi G, D’Ercole S, Petrini M (2023) Antibiotics 12(4)675. Crossref

16 Gomathi R, Paradesi D (2023) Mater Today-Proc 93:54-60. Crossref

17 Ospanova ZhB, Musabekov KB, Kerimkulova MZh (2016) Physico-chemistry of foams and aerosols: educational and methodological manual [Fiziko-khimiya pen i aerozoley: uchebno-metodicheskoye posobiye]. University, Almaty, Kazakhstan. (In Russian) Kazakh National

18 Musabekov KB and others (2013) Laboratory work on colloid chemistry [Laboratornyye raboty po kolloidnoy khimii]. Kazakh National University, Almaty, Kazakhstan. (In Russian)

19 Abdrakhmanova GA (2015) Young scientist 9(89):60-62. (In Russian)
Published
2024-06-28
How to Cite
Ospanova, Z., Bayanova, E., Askarova, D., Amankeldi, F., & Nikulina, E. (2024). Composite detergents with antibacterial properties based on mixtures of cetylpyridinium chloride with Genapol. Chemical Bulletin of Kazakh National University, 111(1-2), 4-11. https://doi.org/https://doi.org/10.15328/cb1354

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