The investigation prospect application of alcohol-water extract of lingonberry as antimicrobial, anti-fungi and antioxidant pharmaceutical

Keywords: lingonberry, leaf, antioxidant power, antimicrobial activity, anti-fungi activity

Abstract

Infection diseases is a worldwide important problem for medicine and pharmacy. Every year 13.7 million people die from bacterial infections in the world. Thus, the search of new compounds with antimicrobial and anti-fungi activity is topical for today. The object of the study was lingonberry leaf 60% extract. The content of phenylpropanoids derivatives was evaluated by spectrophotometric method of analysis, whereas organic acids by alkalimetric method; antioxidant power was found by potentiometric method; antibacterial and antifungal activity was assessed by the method of “wells”.

According to the results of the study, it was shown that the lingonberry leaf extract is inferior to the green tea leaf extract in terms of the content of phenolic compounds, catechins, hydroxycinnamic and organic acids, but flavonoids dominate in the lingonberry extract. The study found that lingonberry leaf extract has a high level of antioxidant activity. When comparing the levels of antioxidant action of lingonberry extract with green tea extract and the «gold standard» – аepigallocatechin-3-O-gallate in one concentration of 0.03 mol/L, it was found that lingonberry extract had the best result. Escherichia coli bacteria was the most sensitive to the extract whereas Pseudomonas aeruginosa was the most resistant.

This work shows that 60% ethanolic lingonberry leaf extract has potent antioxidant, antimicrobial and antifungal effects. According to the obtained results, it can be concluded that 60% V. vitis-idaea leaf extract is promising for the development of new antimicrobial, antifungal and antioxidant pharmaceutical.

Author Biographies

Olexander Y. Maslov, National University of Pharmacy, Kharkov, Ukraine

Assistant of General Chemistry

Mykola A. Komisarenko, National University of Pharmacy, Kharkov, Ukraine

Assistant of the Department of Pharmacognosy and Nutriciology

Svitlana V. Ponomarenko, Mechnikov Institute of Microbiology and Immunology of the NAMS of Ukraine, Kharkov, Ukraine

Leader researcher of Laboratory of Biochemistry and Biotechnology

Tetiana P. Osolodchenko, Mechnikov Institute of Microbiology and Immunology of the NAMS of Ukraine, Kharkov, Ukraine

Head of Laboratory of Biochemistry and Biotechnology

Sergii V. Kolisnyk, National University of Pharmacy, Kharkov, Ukraine

Head of General Chemistry Department

Mykola Yu. Golik, National University of Pharmacy, Kharkov, Ukraine

Professor of General Chemistry Department 

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Published
2024-10-08
How to Cite
Maslov, O., Komisarenko, M., Ponomarenko, S., Osolodchenko, T., Kolisnyk, S., & Golik, M. (2024). The investigation prospect application of alcohol-water extract of lingonberry as antimicrobial, anti-fungi and antioxidant pharmaceutical. Chemical Bulletin of Kazakh National University, 112(3), 4-11. https://doi.org/https://doi.org/10.15328/cb1366