NMR spectroscopic studies of the supramolecular inclusion complexes of 1-(2-etoxyethyl)-4-(hexyne-1-yl)-4-benzoiloxypiperidine with β-cyclodextrin

  • Tulegen Seilkhanov Sh. Ualikhanov Kokshetau State University
  • Lubov Sokolova Sh. Ualikhanov Kokshetau State University
  • Olzhas Seilkhanov Sh. Ualikhanov Kokshetau State University
  • Kaldybay Praliyev A.B. Bekturov Institute of Chemical Sciences, Almaty
  • Tynyshtyk Iskakova A.B. Bekturov Institute of Chemical Sciences, Almaty
DOI: https://doi.org/10.15328/chemb_2014_375-84
Keywords: 1-(2-ethoxyethyl)-4-(hexyne-1-yl)-4-benzoyloxypiperidine, β-cyclodextrin, inclusion complexes, NMR spectroscopy

Abstract

In order to establish the formation of supramolecular inclusion complexes of 1-(2-ethoxyethyl)-4-(hexyne-1-yl)-4-benzoyloxypiperidine with β-cyclodextrin and their structures, 1H and 13C NMR spectra of 1-(2-ethoxyethyl)-4-(hexyne-1-yl)-4-benzoyloxypiperidine and its complexes with β-cyclodextrin were studied. The changes in the values of chemical shifts of 1H and 13C of substrate and receptor in their inclusion complexes with β-cyclodextrin have been determined. It has been established that inclusion complexes formed in the reaction of 1-(2-ethoxyethyl)-4-(hexyne-1-yl)-4-benzoyloxypiperidine with β-cyclodextrin. It was shown that the N-ethoxyethyl’s end of molecule substrates entered in the inner cavity of the receptor.

Author Biography

Tulegen Seilkhanov, Sh. Ualikhanov Kokshetau State University
Head of Laboratoru NMR spectroscopy

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Published
2014-10-31
How to Cite
Seilkhanov, T., Sokolova, L., Seilkhanov, O., Praliyev, K., & Iskakova, T. (2014). NMR spectroscopic studies of the supramolecular inclusion complexes of 1-(2-etoxyethyl)-4-(hexyne-1-yl)-4-benzoiloxypiperidine with β-cyclodextrin. Chemical Bulletin of Kazakh National University, 75(3), 75-84. https://doi.org/https://doi.org/10.15328/chemb_2014_375-84
Issue
Vol 75 No 3 (2014): Chemical Bulletin of Kazakh National University
Section
Organic and Polymers Chemistry
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