Development of the technology for obtaining new hydrogel materials based on acrylic monomers

  • Nazerke Dauletbayevna Nurabay al-Farabi Kazakh National University, Almaty, Kazakhstan https://orcid.org/0000-0001-7354-9502
  • M. Abutalip al-Farabi Kazakh National University, Almaty, Kazakhstan
  • Raikhan Kulymbetovna Rakhmetullayeva al-Farabi Kazakh National University, Almaty, Kazakhstan https://orcid.org/0000-0003-1002-2046
  • Grigoriy Alekseevich Mun al-Farabi Kazakh National University, Almaty, Kazakhstan
Keywords: 2-hydroxyethyl acrylate, N-isopropylacrylamide, acrylic acid, hydrogen bond, gentamicin, lincomycin, hydrophobic interaction

Abstract

Smart water-soluble polymers and hydrogels are capable to reversibly react to insignificant changes of the medium properties (pH, temperature, ionic strength, a presence of some substances, illumination, electric field). The reacting of a system is visible to the naked eye (the formation of a new phase in a homogeneous solution, or compression of the hydrogel). The properties of such polymers and hydrogels are considered. For the first time, the stimuli-responsive polymeric hydrogels based on N-isopropylacrylamide (NIPAAM), 2-hydroxyethyl acrylate (HEA) and acrylic acid (AA) have been synthesized by free initiation of radical copolymerization. The purpose of the research is to obtain stimuli-responsive cross-linked terpolymers based on N-isopropylacrylamide, 2-hydroxyethyl acrylate and acrylic acid and study their physicochemical properties. The physicochemical methods such as scanning electron microscopy, differential scanning calorimetry, infrared spectroscopy, gravimetry, cathetometric and thermogravimetric analyses were used in this study. To determine the thermal and pH – sensitivity of the modified copolymer, the effect of temperature on the NIPAAM-НEA-AA nets (in different pH media) was studied. They are characterized by a thermally induced collapse and a dependence on a medium pH. The interaction of copolymers with drugs such as lincomycin and gentamicin was studied for using the new copolymers as a drug carrier. To study the antibacterial properties and the transportation of physiologically active substances of hydrogel, the elimination of specially prepared bacteria by hydrogels with various medicinal ingredients were conducted.

References

1 Gisser KRC, Geselbracht MJ, Capellari A, Hunsberger L, Ellis AB, Perepezko J, Lisensky GC (1994) J Chem Educ 71:334-340. Crossref

2 Galayev IYu (1995) Russ Chem Rev 64:471-489. Crossref

3 Fujishige A, Kubota K, Ando I (1989) J Phys Chem-US 93:3311-3313. Crossref

4 Kubota K, Fujishige S, Ando I (1990) Polym J 22:15-20. Crossref

5 Byrne ME, Park K, Peppas NA (2002) Adv Drug Deliver Rev 54:149-161. Crossref

6 Safrany A (1999) Radiat Phys Chem 55:121-126.

7 Tarasevich BN (2012) IR spectra of the main classes of organic compounds. Reference materials [IK-spektry osnovnykh klassov organicheskikh soyedineniy. Spravochnyye materialy]. MGU, Moscow, Russia. P.4-29. (In Russian)

8 Nakan U, Rakhmetullayeva RK, Mun GA, Shaihutdinov EM, Toktabayeva AK (2012) Synthesis and physico-chemical properties of copolymers based on N-isopropyl acrylamide and 2-hydroxyethylacrylate. Proceedings of USM – KazNU Conference on Challenges of teaching & chemistry research in institutions of higher learning, Penang, Malaysia. P.30.

9 Kizbayev I, Kurmanbekova AK, Nakan U (2014) New stimuli-sensitive copolymers based on N-isopropylacrylamide [Novye stimulchuvstvitel’nye sopolimery na osnove N-izopropil-akrilamida]. Abstracts of the International conference of students and young scientists “Farabi Alemi”, Almaty, Kazakhstan. P.107. (In Russian)

10 Yasnikov IS, Nagornov YuS, Gorbachev IV, Mikeyev RR, Sadovnikov PS, Shubchinskaya NYu, Aminarov AV (2013) Fundamental research [Fundamental’nye issledovaniya] 1:758-764. (In Russian)
Published
2018-03-14
How to Cite
Nurabay, N., Abutalip, M., Rakhmetullayeva, R., & Mun, G. (2018). Development of the technology for obtaining new hydrogel materials based on acrylic monomers. Chemical Bulletin of Kazakh National University, 87(4), 20-29. https://doi.org/https://doi.org/10.15328/cb959