Synthesis of acetylene alcohols of heterocyclic type and the acyl derivatives
Abstract
A synthesis of potentially biologically active heterocyclic amino alcohols of acetylene (Piperidine and Morpholine) under the conditions of Mannich reaction accomplished and received their acyl derivatives. Pharmacological activity (antibacterial and antispasmotic) of synthesized compounds, also acute toxicological characteristics studied. The study showed that the combination of DMAE-4 has antispasmodic activity with low toxicity.
References
1 Mashkovski MD (1998) Medications of the XX century [Lekarstva XX veka]. Medicine, Moscow, Russia. (In Russian). ISBN 5-7864-0072-7
2 Dyusebaeva MA, Akhmedova ShS (2013) Proceedings of the Scientific-Technical Society KAHAK [Izvestiya nauchno-tehnicheskogo obshestva KAHAK] 4:10-12. (In Russian)
3 Dyusebaeva MA, Akhmedova ShS (2014) Synthesis and study reactivity of ethyl-4-dimethyl oksopiperidil-1-acetic acid [Sintez i izucheniye reaktsionnoy sposobnosti etilovogo efira dimetil -4 - oksopiperidil -1- uksusnoy kisloty]. Proceedings of VIII International Beremzhanov Congress on Chemistry and Chemical Technology, Ust-Kamenogorsk, Kazakhstan. P.243-245. (In Russian)
4 Mukanova MS, Yerzhanov KB (2014) Proceedings of the Academy of Sciences of Kazakhstan. Chemical series [Izvestiya Akademii Nauk. Seriya himicheskaya] 1:130-136. (In Russian)
5 Askerov OV, Veliev MG, Shatirova MI (2009) Chem Нeterocyc Compd 10:1485-1493. (In Russian)
6 Azerang P, Rezayan AH, Sardari S, Kobarfard F, Bayat M, Tabib K (2012) DARU Journal of Pharmaceutical Sciences 20:90. http://dx.doi.org/10.1186/2008-2231-20-90
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-NC-ND 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.