Synthesis of acetylene alcohols of heterocyclic type and the acyl derivatives

  • Moldir Dyusebaeva al-Farabi Kazakh National University
  • Zhanar Zhenis al-Farabi Kazakh National University
  • Sholpan Akhmedova al-Farabi Kazakh National University
Keywords: piperidine, morpholine, acetylenes alcohols, Mannich reaction, biologically activity

Abstract

A synthesis of potentially biologically active heterocyclic amino alcohols of acetylene (Piperidine and Morpholine) under the conditions of Mannich reaction accomplished and received their acyl derivatives. Pharmacological activity (antibacterial and antispasmotic) of synthesized compounds, also acute toxicological characteristics studied. The study showed that the combination of DMAE-4 has antispasmodic activity with low toxicity. 

References

1  Mashkovski MD (1998) Medications of the XX century [Lekarstva XX veka]. Medicine, Moscow, Russia. (In Russian). ISBN 5-7864-0072-7

2  Dyusebaeva MA, Akhmedova ShS (2013) Proceedings of the Scientific-Technical Society KAHAK [Izvestiya nauchno-tehnicheskogo obshestva KAHAK] 4:10-12. (In Russian)

3  Dyusebaeva MA, Akhmedova ShS (2014) Synthesis and study reactivity of ethyl-4-dimethyl oksopiperidil-1-acetic acid [Sintez i izucheniye reaktsionnoy sposobnosti etilovogo efira dimetil -4 - oksopiperidil -1- uksusnoy kisloty]. Proceedings of VIII International Beremzhanov Congress on Chemistry and Chemical Technology, Ust-Kamenogorsk, Kazakhstan. P.243-245. (In Russian)

4  Mukanova MS, Yerzhanov KB (2014) Proceedings of the Academy of Sciences of Kazakhstan. Chemical series [Izvestiya Akademii Nauk. Seriya himicheskaya] 1:130-136. (In Russian)

5  Askerov OV,  Veliev MG,  Shatirova MI (2009) Chem Нeterocyc Compd 10:1485-1493. (In Russian)

6  Azerang P, Rezayan AH, Sardari S, Kobarfard F, Bayat M, Tabib K (2012) DARU Journal of Pharmaceutical Sciences 20:90. http://dx.doi.org/10.1186/2008-2231-20-90

Published
2015-03-31
How to Cite
Dyusebaeva, M., Zhenis, Z., & Akhmedova, S. (2015). Synthesis of acetylene alcohols of heterocyclic type and the acyl derivatives. Chemical Bulletin of Kazakh National University, 77(1), 36-43. https://doi.org/https://doi.org/10.15328/cb490