Development of hydrogel ointments with antituberculosis activity

  • M. Buribayeva al-Farabi Kazakh National University
  • Galiya Irmuhametova al-Farabi Kazakh National University
  • Grigoriy Mun al-Farabi Kazakh National University
DOI: https://doi.org/10.15328/chemb_2013_270-74
Keywords: transdermal therapeutic system, drug delivery, polyvinylpyrrolidone, isioniazid, ethambutol

Abstract

In this work hydrogel ointments based on biopolymer for use as a transdermal therapeutic drug delivery systems for antituberculosis drug substances were obtained and studied. Ointments based on polyvinylpyrrolidone (PVP) with drugs isoniazid and ethambutol were created. The transdermal characteristics of ointments based on PVP and drug were investigated using a cellulose membrane and pig skin. The experiment was carried out on the device Franz cell. Diffusion coefficient (D), the permeability (P) and the permeation rate (F) of the drug were determined.

References

1. Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev., 2004, no 3. Р. 115–24.

2. Wang Y, Thakur R, Fan Q, Michniak B. Transdermal iontophoresis: combination strategies to improve transdermal iontophoretic drug delivery. Eur J Pharm Biopharm., 2005, no 60. Р.179–91.

3. Barry BW. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci., 2001, no 14. Р. 101–14.

4. Jasti BR, Abraham W, Ghosh TK. Transdermal and Topical drug delivery systems In : Ghosh TK, Jasti BR, editors. Theory and Practice of Contemporary Pharmaceutics. 1st ed. Florida: CRC Press; 2005. p. 423-53.

5. D.A.Harkevich. Pharmacology [Farmakologiya]. Textbook for high schools. 8 ed.. Moscow: GEOTAR Media, 2005. P.596-604.

Published
2013-05-14
How to Cite
Buribayeva, M., Irmuhametova, G., & Mun, G. (2013). Development of hydrogel ointments with antituberculosis activity. Chemical Bulletin of Kazakh National University, 70(2), 70-74. https://doi.org/https://doi.org/10.15328/chemb_2013_270-74
Issue
Vol 70 No 2 (2013): Chemical Bulletin of Kazakh National University
Section
Organic and Polymers Chemistry
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-NC-ND 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Most read articles by the same author(s)