Study of physico-chemical properties of the new film-type material based on ethyl acrylate and 2-hydroxyethyl acrylate
Abstract
During recent years the complexes based on water swellable hydrophilic polymers with the drugs and preparation of the film materials used in medicine have attracted attention of researchers. Due to the controlled release of drugs and low toxicity, the polymeric film materials are used as drug delivery systems and dressings.
Polymeric film materials for drug delivery were obtained first time by grafting 2-hydroxyethyl acrylate (HEA) and ethyl acrylate (EA) monomers onto polyvinyl alcohol (PVA). In this study, it was found that the films obtained without thermal treatment are soluble in an aqueous medium. Thus, they were heat treated in the range of 1-15 hours at 90-150ºC. Physico-chemical properties of the films have been studied depending on environmental effects as well as methods of obtaining films have been investigated. An increase of the thermal treatment time leads to a decrease in the degree of swelling and reduces the solubility properties of composite materials. The surface morphology and thermal properties of films based on HEA-EA were investigated by scanning electron microscopy, thermogravimetric analysis and differential scanning calorimetry. It was shown that the surface of obtained films were homogeneous without any bubbles.
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