Hydrogel dressings with local anesthetic action

  • Ayauzhan Tumabayeva al-Farabi Kazakh National University
  • Grigoriy Mun al-Farabi Kazakh National University
  • G. Temirkhanova al-Farabi Kazakh National University
  • B. Karabayeva al-Farabi Kazakh National University
DOI: https://doi.org/10.15328/chemb_2013_281-85
Keywords: lidocaine hydrochloride (LD), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) polymeric hydrogel, drug, copolymer, local anesthetic action, hydrogel dressing

Abstract

The association of the local anesthetic lidocaine hydrochloride (LD) with polyvinylpyrrolidone (PVP) in aqueous solution was investigated. It was shown that titration of PVP aqueous solution with lidocaine accompanied by an increase of viscosity. This indicates the   complexation between charged molecules of anesthetic and macromolecules of PVP. As a result of such non-ionic interaction the PVP macromolecules charges and has the properties of polyelectrolyte. The polymer matrix based on lidocaine hydrochloride and PVP was synthesized. Complexation of matrix components was studied by IR-spectroscopy. 

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Published
2013-05-14
How to Cite
Tumabayeva, A., Mun, G., Temirkhanova, G., & Karabayeva, B. (2013). Hydrogel dressings with local anesthetic action. Chemical Bulletin of Kazakh National University, 70(2), 81-85. https://doi.org/https://doi.org/10.15328/chemb_2013_281-85
Issue
Vol 70 No 2 (2013): Chemical Bulletin of Kazakh National University
Section
Organic and Polymers Chemistry
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